Document Type

Thesis - Open Access

Award Date

2016

Degree Name

Master of Science (MS)

Department

Health and Nutritional Sciences

First Advisor

Gary P. Van Guilder

Abstract

A powerful therapy against microvascular endothelial ischemia-reperfusion injury is remote ischemic preconditioning (rIPC), which triggers tissue protection by exposing a limb to small cycles of vascular occlusion. Animal models indicate that CVD risk factors reduce the protective benefits of ischemic conditioning. However, there are no human studies investigating how a burden of risk factors interferes with rIPC to prevent endothelial injury. The purpose of the present study was to determine the influence of risk factor burden on the capacity of rIPC to prevent endothelial reperfusion injury in humans. Twenty-two (age: 45±14 yr., BMI: 31±8 kg/m2) sedentary adults (12 lower burden: ≤2 risk factors; 10 raised burden: 3-5 risk factors) were studied. Digital arterial tonometry (EndoPAT 2000, Itamar Medical Inc.) was used to assess microvascular endothelial vasodilation during reactive hyperemia before and after 65 min of left arm reperfusion injury (20 min brachial artery ischemia followed by 45 min reperfusion) that was preceded by rIPC (right arm: 3X5 min ischemia/reperfusion). All subjects provided written informed consent according to the Internal Review Board guidelines at South Dakota State University. Repeated measures ANOVA was used to assess group differences between the reactive hyperemia index (RHI) before and after reperfusion injury. Statistical significance was set at P

Description

Includes bibliographical references (page 64-70)

Format

application/pdf

Number of Pages

79

Publisher

South Dakota State University

Rights

Copyright © 2016 Tiffany Trachte

Comments

Cardiovascular system -- Diseases -- Risk factors

Heart -- Diseases -- Risk factors

Reperfusion injury -- Prevention

Myocardial infarction -- Prevention

Cardiotonic agents

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