Article Title

Quantitative Analysis of Endocytosis of Macrophage Growth Factor Receptor by Molecular Imaging

Authors

Victor Georgiev, South Dakota State UniversityFollow
Emily Toering, South Dakota State UniversityFollow
Christopher Callahan, South Dakota State UniversityFollow

Faculty Mentor

Adam Hoppe

Abstract

Endocytosis is a critical cellular process responsible for nutrient uptake, sampling the environment, and cellular signaling. Endocytosis of growth factor receptors is an important step in the regulation of receptor signaling functions. The macrophage growth factor receptor controls growth and differentiation of macrophages, however, the pathway by which the receptor is internalized is not well understood. The analysis showed that for the first time, knockout of endophilin A2 decreases the internalization of macrophage growth factor receptor in primary bone marrow macrophages. This shows that fast endophilin-mediated endocytosis plays a role in the control of the amount of growth factor receptors internalized in macrophages.

Recommended Citation

Georgiev, Victor; Toering, Emily; and Callahan, Christopher (2017) "Quantitative Analysis of Endocytosis of Macrophage Growth Factor Receptor by Molecular Imaging," The Journal of Undergraduate Research: Vol. 14, Article 7.
Available at: https://openprairie.sdstate.edu/jur/vol14/iss1/7