Plan B - Open Access
Master of Science (MS)
Biology and Microbiology
The Hedgehog (Hh) signaling pathway plays a crucial role during embryonic development as well as tissue maintenances in adults. Deregulated Hh signaling has been implicated in different diseases and conditions including cancer. Previously, the mechanisms of Hh signaling pathway and its role in cancer formation have been studied and has led to the development of therapeutic drugs. Among those agents, vismodegib and sonidegib are FDA approved drugs to treat basal cell carcinoma and other cancers. Up to date, several hedgehogs (Hh) signaling inhibitors and drugs have been made and evaluating for cancer treatment. In this review, I will discuss the mechanisms of action of Hh signaling pathway, targeted components, and Hh inhibitors and clinical importance as well as side effects, current evidences, and drug resistance.
Number of Pages
South Dakota State University
Copyright © 2020 Haileselassie Tefera,
Tefera, Haileselassie, "Hedgehog Signaling Inhibators and Their Importance for Cancer Treatment" (2020). Biology and Microbiology Graduate Students Plan B Research Projects. 14.