Plan B - Open Access
Master of Science (MS)
Biology and Microbiology
Fracture nonunions comprise one of the serious clinical complications in orthopedics. Fracture nonunions result when the time to union is greater than 6 to 9 months. It is estimated that approximately 5% to 10% of all fractures progress to fracture nonunion due to a host of complicating patient variables and risk factors. New scoring systems have emerged which help in directing the treatment strategies. Fracture nonunion management should be directed toward maintaining the diamond concept which introduces osteogenic cells lines, an osteoconductive scaffold for those cells to grow, as well as the necessary growth factors, and a stable mechanical microenvironment. This paper will focus on some of the promising research that has been done in the field of orthopedics for the treatment of fracture nonunion, particularly the use of mesenchymal stem cells, bone marrow aspirates, and biophysical manipulations such as the use of electromagnetic fields, and their effects on cell cultures, animal models, and clinical studies.
Number of Pages
South Dakota State University
Copyright © 2021 Zebadiah Nelson
Nelson, Zebadiah, "Current and Future Perspectives in the Treatment of Fracture Nonunions" (2021). Biology and Microbiology Graduate Students Plan B Research Projects. 31.