Document Type

Article

Publication Date

4-2012

Abstract

2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography–tandem mass spectrometry (LC–MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure.

Publication Title

Journal of Chromatography B

Volume

891-892

First Page

81

Last Page

84

Format

application/pdf

DOI of Published Version

10.1016/j.jchromb.2012.01.024

Publisher

Elsevier

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S.

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