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Document Type

Thesis - University Access Only

Award Date


Degree Name

Master of Science (MS)


Animal Science

First Advisor

Michael G. Gonda


E.Coli 0157, BVDV, vaccination, antibody response, cattle


E. coli O157 Siderophore Receptors and Porins (SRP) and Bovine Viral Diarrhea Virus (BVDV) vaccines can protect the host against shedding of E. coli O157 and the infection of BVDV. However, no study has reported the phenotypic correlation of E. coli O157 SRP and BVDV vaccine response with birth and weaning weight in cattle. If an unfavorable correlation existed between E. coli O157 or BVDV vaccine response and weaning weight, for example, selecting for higher E. coli O157 or BVDV vaccine response would result in lighter weaning weights. Furthermore, T-cell response after Foot-and-Mouth Disease Virus (FMDV) vaccination has been unfavorably correlated with weight at vaccination in cattle. Therefore, we hypothesized that humoral response following E. coli O157 and BVDV vaccination was unfavorably correlated with birth and weaning weight in cattle. To test our hypothesis, a total of 676 calves (from USDA-ARSMARC) were vaccinated with E. coli O157 SRP vaccine (Epitopix, Willmar, MN) and a total of 248 calves (from SDSU Antelope Research Station) were vaccinated with Bovi- Shield® GOLD 5 (Zoetis, NY), which includes BVDV. E. coli O157- and BVDV specific- antibody following E. coli O157 and BVDV vaccination was measured by indirect enzyme-linked immunosorbent assay (ELISA). Birth weights were recorded within 48 hours of birth; weaning weights were collected at time of the booster shot. The phenotypic correlations were calculated with Pearson Correlation Coefficients, and a regression model was used to estimate effects of age, gender, age of dam, birth and weaning weight on E. coli O157 and BVDV vaccine response. We did not find a phenotypic correlation of E. coli O157 SRP or BVDV vaccine response with birth or weaning weight. Further studies need to investigate the phenotypic and genetic correlation of humoral and T-cell response following vaccination with weight traits in calves.

Library of Congress Subject Headings

Bovine viral diarrhea virus--vaccination
Cattle--virus diseases--vaccination
Escherichia coli


Includes bibliographical references



Number of Pages



South Dakota State University


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