Optimization of Microfluidic Particle Separator Geometry Using Computational Fluid Dynamics

Author

Joseph Petersen, South Dakota State UniversityFollow

Document Type

Thesis - Open Access

Award Date

2018

Degree Name

Master of Science (MS)

Department / School

Mechanical Engineering

First Advisor

Jeffrey Doom

Keywords

circulating tumor cell, computational fluid dynamics, microfluidic, microtechnology

Abstract

Computational fluid dynamics software was used to simulate the motion of circulating tumor cells in a variety of microfluidic cell isolation devices. Design of several novel microfluidic cell isolation devices was aided by viewing streamlines of fluid in devices in simulation. Devices that performed best in simulation used 5-micrometer wide guiding channels to guide cells to the capture location in the device. While these devices performed better than other devices in simulation and captured all particles regardless of position along inlet, experimental results differ from simulation.

Library of Congress Subject Headings

Microfluidics.
Cell separation.
Cancer cells.
Computational fluid dynamics.

Description

Includes bibliographical references (pages 33-34)

Format

application/pdf

Number of Pages

44

Publisher

South Dakota State University

Recommended Citation

Petersen, Joseph, "Optimization of Microfluidic Particle Separator Geometry Using Computational Fluid Dynamics" (2018). Electronic Theses and Dissertations. 2419.
https://openprairie.sdstate.edu/etd/2419