Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)




With the introduction of numerous and more complex drugs in medicine annually, the metabolism of drugs by liver microsomal enzymes and factors influencing their metabolism has become a subject of increasing interest. A variety of drugs are metabolized by enzyme systems located in liver microsomes (1). Reactions catalyzed by these enzymes include N-dealkylation, deamination, aromatic hydroxylation, ether cleavage, alkyl chain oxidation, azo link cleavage, sulfoxide formation, and glucuronide formation. The report that 3’-methyl -4- dimethylaminazobenzene, a potent liver carcinogen, did not cause hepatomas in rats when administrated with 3-methylcholanthrene (2) stimulated early investigations to study the effects of various chemical compounds on drug metabolizing enzymes found in liver microsomes. Since this first investigation numerous studies have been done with a variety of drugs in an effort to obtain information concerning the mechanism involved in drug potentiation and synergism. The ability is paralleled in vivo by an accelerated rate of drug metabolism and by a shortened duration of drug action. The results of this study may be useful in the final evaluation of the mechanism of action and norethandrolone and similar compounds.

Library of Congress Subject Headings

Drugs -- Metabolism




South Dakota State University