Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)




Tuberculosis is still one of the major threats to the health of mankind. Attempts to find suitable chemotherapeutic agents for tuberculosis date almost from the time that Koch (1, 2, 3) announced the discovery of the etiological agent of this disease. The earlier work has been reviewed by Long (3, 18). The modern chemotherapeutic era, however, began when Rich and Follis (3, 29) demonstrated that sulfa-nilamide exerted a light suppressive effect on the course of experimental tuberculosis in guinea pigs. Since that time, numerous investigators (1, 2, 4-14, 16-18, 29, 36, 39, 41-44) have attempted to find chemotherapeutic agents suitable for the treatment of tuberculosis. Their efforts have been rewarded by the discovery of streptomycin, P-aminosalicylic acid, isoniazid, and a variety of other clinically useful but less effective drugs (18). None of these, however, either alone or in combination achieve completely satisfactory therapeutic results because, in spite of intensive treatment, tuberble pacilli may persist in tissue or in lesions for long periods of time (2, 29). There is, therefore a real need for new eradicative drugs. The purpose of this work was to determine whether tubercular substances were present in a sample consisting of a mixture of soil and decayed animal tissue.

Library of Congress Subject Headings

Mycobacterium tuberculois




South Dakota State University