Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)




The iron deficiency anemia found particularly in swine has a high incidence in the newborn. The nutrition of the sow inversely affects progression of the anemia. Newborn nutritional status, also, inversely augments the anemic condition. The anemia does not become apparent in the newborn until a few days following parturition. There is a drastic decrease in iron availability with succeeding decreases in normal hemoglobin formation and mature red blood cell formation. An important factor along with these conditions is susceptibility to disease leading to death. A gradual return to normal follows if the newborn survives the anemic period. This condition is of economic significance to the swine producer for a variety of reasons. The newborn piglet faces initially a fast growing period with a small reserve of storage iron for the developing tissues. The stored iron is quickly depleted and the anemia becomes apparent. The resulting erythropoietic malfunction may possibly be alleviated by prepartum maternal treatment and/or postpartum newborn treatment. Postpartum treatments may add additional stresses to the newborn enhancing the anemic condition. Enhanced hemoglobin precursor transfer to the fetus may be of primary importance in carrying the newborn past the critical anemic period. The primary factor concerned with iron incorporation into the erythron and hemoglobin synthesis is the hormone, erythropoietin. Several chemicals are being evaluated at the present time to provide an agent(s) that will successfully enhance hematological parameters of the newborn. A promising drug, dibenzyline, elicits serum iron level changes and increases peripheral blood flow. The purpose of this study was to investigate selected hemogram parameters in pregnant rabbits and fetuses following prepartum treatments involving dibenzyline, injectable iron, and erythropoietin which may enhance hemogram parameters.

Library of Congress Subject Headings

Iron deficiency anemia
Rabbits -- Disease



Number of Pages



South Dakota State University