Document Type

Thesis - Open Access

Award Date

1988

Degree Name

Master of Science (MS)

Department

Chemistry

First Advisor

Duane P. Matthees

Abstract

Mycophenolic acid is toxic to animals consuming it beyond a certain level and possesses antitumor activity. Not many methods for its trace analysis in feedstuffs and agricultural products have been reported. Thus, it is desirable to develop a standard analytical technique for such important compounds. The purpose of this investigation is to develop a technique or method sensitive enough to determine trace quantities of the compound. The method developed is based on solvent extraction from feedstuffs and detection by high performance liquid chromatography. Solvent extraction methods have given good results with low background interferences when cleaned up by column chromatography and/or acid base partitioning (for some grain samples only). High performance liquid chromatography was chosen for the detection of mycophenolic acid because it offers a high degree of sensitivity and selectivity with very few background interferences when compared to gas chromatography.

Library of Congress Subject Headings

Feeds -- Contamination

Feeds -- Analysis

Chromatographic analysis

Format

application/pdf

Number of Pages

59

Publisher

South Dakota State University

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