Thesis - Open Access
Master of Science (MS)
The dominant AY gene of the agouti locus (linkage group V) in the house mouse (Muse musculus) is one of approximately eleven alleles specifying coat color. Homozygosity of the AY allele is thought to cause death of the embryo in utero around the time of implantation. For this reason the AY/AY genotype is called the lethal yellow mouse. The precise time that the primary gene defect is first expressed is not known. Attempts to pinpoint the phenocritical period in an effort to discover the basic biochemical alteration specified by the lethal gene have thus far be unsuccessful. An in vitro analysis was therefore undertaken to meet the following objectives: 1. Define morphological characteristics that will identify the class of AY/AY homozygotes in preimplantation embryo culture, 2. Discover the extent of the phenocritical period of AY homozygotes, 3. Discover if AY homozygotes are in fact implantation lethals and 4. Test the background variability and abnormalities occurring in control crosses as compared to the experimental cross.
Library of Congress Subject Headings
Number of Pages
South Dakota State University
Johnson, Linda L., "In Vitro Analysis of Pre- and Early Postimplantation Development of Lethal Yellow (Ay/Ay) Mouse Embryos" (1977). Electronic Theses and Dissertations. 5080.