Narrative Review of the Relationship between Depression and Low Blood Folate and Vitamin B12 Levels
Plan B - Open Access
Master of Science (MS)
Health and Consumer Sciences
Depression, Serum Folate, Serum Vitamin B12
Depression is a common psychological mood disorder that impacts more than 16 million adults in the United States. It can impact several areas of a person’s life including physical activity, diet and daily activities. The role of nutrition in depression therapy has been researched for several years, with folate and vitamin B12 being the main highlights. Folate and vitamin B12 play a vital role in the development of the central nervous system and conversion of homocysteine to methionine. Past research has found inconsistent findings regarding the relationship between folate, vitamin B12 and their role in depression. This article dives into the existing research to evaluate why there is an inconsistency. A total of 13 studies met the criteria and were included in the review. The findings from these studies show the inconsistency of the research, with some studies finding a relationship and others finding no relationship. Several studies imply that depression can increase the chance of individuals developing vitamin deficiencies, which can increase the severity of depression symptoms. However, there are studies that have found no relationship between folate, vitamin B12 and depression. Several limitations need to be addressed and continued research needs to be done before a conclusive answer be provided.
Number of Pages
South Dakota State University
© 2022 Jenifer Sip
Sip, Jennifer, "Narrative Review of the Relationship between Depression and Low Blood Folate and Vitamin B12 Levels" (2022). Health and Nutritional Sciences Graduate Students Plan B Capstone Projects. 13.