The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance
We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P
Clinical pharmacology and therapeutics
DOI of Published Version
American Society for Clinical Pharmacology and Therapeutics
Pretorius, M M; Gainer, J V; Van Guilder, Gary; Coelho, E B; Luther, J M; Fong, P; Rosenbaum, D D; Malave, H A; Yu, C; Ritchie, M D; Vaughan, D E; and Brown, N J, "The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance" (2008). Health and Nutritional Sciences Faculty Publications. 55.