urinary calculi, silica, phosphorus, calcium, ammonium chloride, sodium bicarbonate
An animal model utilizing Sprague-Dawley rats fed a diet containing 2% of tetraethylorthosilicate (TES) has been used to study urinary conditions and dietary factors preventing silica urinary calculi . The basal TES diet produced approximately a 50% incidence of silica urinary calculi. Supplemental dietary phosphorus and the urinary acidifying agent ammonium chloride greatly reduced the urinary calculi incidence, while supplemental dietary calcium and urine alkalinization with sodium bicarbonate increased the incidence. The protection from silica urinary calculi provided by sodium or ammonium phosphate compounds was found to be independent of their urinary acidifying effects, and the effects of phosphates and ammonium chloride were additive. While these observations have not been extended t o cattle and sheep, high silica range grasses often contain suboptimum levels of phosphorus. Therefore, the feeding of phosphorus supplements free choice to animals on the range appears to be a sensible management practice that may help prevent silica urinary calculi.
Number of Pages
South Dakota State University
Copyright © 1986 South Dakota State University
Emerick, Royce J.; Schreier, Carl J.; and Lu, Donghao, "Prevention of Silica Urinary Calculi in a Laboratory Animal Model" (1986). South Dakota Beef Report, 1986. 8.