Evaluation of a Macrophage Attenuated Isolate of PRRSV as a Vaccine for Porcine Reproductive and Respiratory Syndrome Virus
PRRS continues to be the most economically important disease of swine. While the acute reproductive disease is still prevalent, chronic, or endemic PRRS in nursery and grow/finish pigs is a major problem confronting most swine producers. Post-weaning problems in these herds include a 50-85% reduction in growth rates; a 10-30% increase in unmarketable pigs; and a 10-25% increase in psot-weaning morality. Popular protocols to manage PRRSV infections include bredding herd stabilization; elmination of seronegative sub-populations of susceptible gilts; nursery depopulation; and more recently mass vaccination/unidirectional pig flow in the grow/finsih unit. The goal of this project is to determine if an isolate of PRRSV, that has been moditifed by serial passage in monkey kidney cells (MARC-145) and replicates at very low levels in procine alveolar macrophages, is avirulent for pigs an pregnant gilts.
Number of Pages
South Dakota State University
Copyright © 2001
Nelson, C.D.; Rowland, R.R.; Zeman, D.H.; and Benfield, D.A., "Evaluation of a Macrophage Attenuated Isolate of PRRSV as a
Vaccine for Porcine Reproductive and Respiratory Syndrome Virus" (2002). South Dakota Swine Research Report, 2001. 20.