Document Type

Thesis - Open Access

Award Date

2017

Degree Name

Master of Science (MS)

Department

Health and Nutritional Sciences

First Advisor

Gary P. Van Guilder

Keywords

cardioprotection, cardiovascular disease, endothelial function, ischemia-reperfusion injury, ischemic conditioning, revascularization surgery

Abstract

Remote ischemic postconditioning (rIpost) is a potent vasculoprotective stimulus that is thought to reduce reperfusion injury associated with heart disease. However, certain animal models of cardiometabolic risk factors such as dyslipidemia, diabetes, and hypertension suggest the beneficial effects of rIpost to lessen reperfusion injury may be diminished. These findings have not been studied in clinically relevant humans. The aim of this study was to determine whether the protective effects of rIpost are reduced in the context of raised cardiometabolic risk in humans. Seven participants with raised cardiometabolic risk burden (age:57±7 years; BMI: 31±4kgm2participated in this 2X2 randomized cross-over design study. Raised cardiometabolic risk was established by the presence of 2 or more major risk factors and a 10-year Framingham risk score ≥10%. Microvascular endothelial function was measured using peripheral arterial tonometry (EndoPAT 2000, Itamar Medical Inc.) before and after 20 minutes of left arm, brachial artery ischemia, with and without the induction of rIpost (three, 5-minute bouts of right arm ischemia and reperfusion at 220 mmHg). Remote Ipost procedures were initiated immediately at the onset of reperfusion injury. Microvascular endothelial function was also assessed during a sham trial consisting of mock occlusions at the brachial artery (three, 5-minute inflations at 20 mmHg).

Library of Congress Subject Headings

Cardiovascular system -- Diseases -- Risk factors.
Heart -- Diseases -- Risk factors.
Reperfusion injury -- Prevention.
Myocardial infarction -- Prevention.
Cardiotonic agents.

Description

Includes bibliographical references (pages 67-71)

Format

application/pdf

Number of Pages

80

Publisher

South Dakota State University

Rights

Copyright © 2017 Brian M. Hemenway

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