Quantitative Bone Analysis in Children: Current Methods and Recommendations.
Absorptiometry, Photon, Bone Density, Bone Diseases, Metabolic, Bone and Bones, Child, Humans, Mass Screening, Tomography, X-Ray Computed, Ultrasonography
Over the past decade there have been an increasing number of published manuscripts dealing with pediatric bone mineral density (BMD). The reason for this interest is 2-fold. First, there is a belief that bone gained early in life is an important factor in determining the risk of osteoporosis later in life. Second, there is a desire to identify children who may benefit from drugs that are becoming available for use in treating osteopenia and osteoporosis. Despite the interest, there are several important issues with assessing BMD or the amount of bone (bone mineral content [BMC] or bone mass) that are unique to children that need to be recognized and are discussed in this review. Dual energy x-ray absorptiometry (DXA) is the most common method for assessing BMD and BMC, but other methods, including peripheral quantitative computed tomography (pQCT) and quantitative ultrasonography (QUS), may provide important additional information on bone size, geometry, and quality, and these methods also are discussed.
The Journal of Pediatrics
DOI of Published Version
Specker, Bonny and Schoenau, Eckhard, "Quantitative Bone Analysis in Children: Current Methods and Recommendations." (2005). Ethel Austin Martin Program Publications. 37.