Determinants of Bone Mineral Content in Children

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Book Chapter

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Bone is a vital connective tissue that allows for structural support, locomotion and serves as a critical reserve for mineral homeostasis. The inorganic phase of bone, which makes up approximately 70% of its weight, is primarily a calcium phosphate mineral analogous to crystalline hydroxyapatite. Approximately 98% of the organic phase of bone is type I collagen. Noncollagenous proteins in bone include osteocalcin, osteopontin, fibronectin and others. These organic bone components contribute to bone structure and biological function, and their measurement in serum can provide information on bone resorption and formation.

Publication Title

Annales Nestle' : Calcium in Childhood 2



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