Eriks Leitis

Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)

Department / School



The problem of selenium poisoning has been extensively reviewed. Although a considerable amount of work has been done on this problem, the mechanism of the toxic action of selenium is not understood. This work has undertaken as part of an effort to determine the nature of the protective effect of certain substances against selenium poisoning, in that this might aid in understanding its toxic action. The conflicting findings concerning the effectiveness of methionine against selenium poisoning were obtained with a variety of diets and under a variety of other experimental conditions. It appeared, therefore, that certain unknown factors or conditions might be necessary for methionine to be active as a protectant. It was decided that a semi-purified diet containing 10 p.p.m. of selenium as sodium selenite and male albino rats weighing about 70 grams should be used for further study of the problem. With such standardized conditions and with a diet of constant and well-defined composition the unknown factors might be determined. Part of the work discussed here deals with the effectiveness of methionine and related compounds against selenium poisoning under these conditions.

Library of Congress Subject Headings

Selenium -- Physiological effect
Linseed oil


Includes bibliographical references (pages 37-38)



Number of Pages



South Dakota State University


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