Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)

Department / School



In many semi-arid regions plants may take up toxic quantities of selenium. If livestock consume very large amounts of such plants they will ingest enough selenium to produce toxic symptoms. This presents a serious problem to the farmers and ranchers in such areas is certainly the cause of much financial loss.

Since the discovery by Franke in 1934 that selenium was the cause of the condition then known as “alkali disease”, a great deal of work has been done on the problem of selenium poisoning. As a result of this research, several substances have been discovered which give complete or at least partial protection against selenium poisoning. Although protection by certain compounds has been established, very little work has been done which aids in the elucidation of the actual mechanism involved in the protective action. Recently it has been shown that reduction of selenite inhibition of yeast respiration by arsenite and lactate was due to interference with a concentrating mechanism. This study was undertaken in the hope that an investigation of the effect of these substance on selenium distribution in the rat might provide new information as to the mechanism of the protective action.

Library of Congress Subject Headings

Selenium -- Physiological effect


Includes bibliographical references (pages 36-38)



Number of Pages



South Dakota State University


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