Document Type

Thesis - Open Access

Award Date

2020

Degree Name

Master of Science (MS)

Department / School

Mechanical Engineering

First Advisor

Anamika Prasad

Keywords

Bone Tissue Engineering, Cellulose Acetate, Electrospinning, FT-IR, Potassium Chloride, SEM

Abstract

Cellulose Acetate (CA) based biomaterials are being used as substrates for bone ingrowth applications due to their nontoxic and nonirritant nature coupled with optimum morphology and stiffness. Electrospinning with additives and/or post-treatment has emerged as a viable protocol to further improve mechanical properties of CA and expand its utility. Herein, we highlight the role of potassium chloride (KCl) in association with airdrying to enhance the elastic modulus and tensile strengths of CA fibers. Salt aggregation in between fibers is observed through Scanning Electron Microscopy (SEM), however, Fourier-transform infrared (FTIR) analysis signifies the interactions between K+ ions and acetyl groups. The increase in KCl concentration (2 to 4 to 6%) boosts the elastic modulus to 176 MPa (52 times than pure CA) and tensile strength to 1.2 MPa (9 times than pure CA). The presence of K+ ions, indeed, offers osteoconduction to fibers and thus the outcome has potential in bone tissue engineering applications.

Library of Congress Subject Headings

Tissue engineering.
Tissue scaffolds.
Electrospinning.
Bone regeneration.
Cellulose acetate.
Potassium chloride.
Hydroxyapatite.

Format

application/pdf

Number of Pages

66

Publisher

South Dakota State University

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Rights Statement

In Copyright