Thesis - Open Access
Master of Science (MS)
Bone Tissue Engineering, Cellulose Acetate, Electrospinning, FT-IR, Potassium Chloride, SEM
Cellulose Acetate (CA) based biomaterials are being used as substrates for bone ingrowth applications due to their nontoxic and nonirritant nature coupled with optimum morphology and stiffness. Electrospinning with additives and/or post-treatment has emerged as a viable protocol to further improve mechanical properties of CA and expand its utility. Herein, we highlight the role of potassium chloride (KCl) in association with airdrying to enhance the elastic modulus and tensile strengths of CA fibers. Salt aggregation in between fibers is observed through Scanning Electron Microscopy (SEM), however, Fourier-transform infrared (FTIR) analysis signifies the interactions between K+ ions and acetyl groups. The increase in KCl concentration (2 to 4 to 6%) boosts the elastic modulus to 176 MPa (52 times than pure CA) and tensile strength to 1.2 MPa (9 times than pure CA). The presence of K+ ions, indeed, offers osteoconduction to fibers and thus the outcome has potential in bone tissue engineering applications.
Number of Pages
South Dakota State University
In Copyright - Non-Commercial Use Permitted
Sinha, Ruhit, "Development of Cellulose Acetate-Based Scaffold for Bone Tissue Engineering Applications" (2020). Electronic Theses and Dissertations. 3938.
Available for download on Tuesday, December 15, 2020