Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)

Department / School

Health and Nutritional Sciences

First Advisor

Bradley Bowser


Purpose: To evaluate the effectiveness of progressive resistance training (PRT), with the inclusion of balance and stretching exercises, on the timed up and go (TUG) task. Specifically, we investigated the TUG in regard to changes in timing variables for the entire movement and the subphases, in association with muscular strength, ambulation, fatigue, and perceived disability in patients with Multiple Sclerosis (PwMS).
Methods: Fifteen PwMS volunteered twice weekly for a twelve-week PRT exercise training program. The participants underwent an assessment at baseline (strength assessments using a Biodex dynamometer and one repetition max (1RM); the TUG and its subphases using Qualysis Track Manager; and the six-minute walk test (6MWT) and patient oriented outcome measures (POOMs). In subsequent sessions, the strength training intervention was conducted. Following the intervention, baseline assessments were re-performed to establish post training values.
Results: Muscular strength showed an increased percent change for isometric testing (11% for the left leg and 5.5% for the right leg). Isokinetic variables improved for both testing parameters, as well as the 1RM for the leg press (p ≤ 0.05). Total TUG time decreased by (8%). The sit to stand phase significantly improved (22%) as evidenced by an improvement in trunk flexion (18.5%) and rise time (24.6%). Timing from the start of the movement to the three-meter mark improved significantly (12.8%). Self-reported fatigue and patient reported affliction from MS also decreased (p ≤ 0.05) following the intervention.
Conclusion: PwMS are capable of making positive changes in the timing variables for the TUG by increasing muscular strength following a PRT program. These changes are associated with improved QOL and decreased fatigue.

Library of Congress Subject Headings

Multiple sclerosis -- Exercise therapy.
Isometric exercise.
Muscle strength.

Number of Pages



South Dakota State University

Included in

Kinesiology Commons



Rights Statement

In Copyright