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Document Type

Dissertation - University Access Only

Award Date

2003

Degree Name

Doctor of Philosophy (PhD)

Department

Nutrition, Food Science, and Hospitality

First Advisor

Bonny Specker

Abstract

The positive relationship between circulating leptin concentrations and measures of body fat is well characterized and has been extensively demonstrated among human study populations by previous investigators (6-13). However, few data are available on the relationship between regional fat mass and circulating leptin concentrations (12, 13). Currently, there is no compelling evidence that circulating leptin concentrations predict body fat distribution. Despite contrary in vitro evidence (14-16), previous studies among adult humans have indicated no or only weak relationships between bone outcomes and circulating leptin concentrations (17-29). We studied effects of circulating leptin on regional bone mass (bone mineral content, BMC) and body composition by dual energy x-ray absorptiometry (DXA) in 345 Hutterite (H, n=264, n=l52 female) and non-Hutterite (NH, n=8 l, n=46 female) individuals ages 20 to 55 years. We tested the following hypotheses: 1) There will be a strong correlation between whole body (WB) percentage fat mass and circulating leptin concentrations among South Dakota Rural Bone Health Study (SDRBHS) participants ages 20 to 55 years. 2) Controlling for covariates including WB percentage fat mass, there will be no relationship between trunk percentage fat mass and circulating Ieptin concentrations among SDRBHS participants ages 20 to 55 years. 3) Controlling for covariates including WB percentage fat mass, there will be no relationships between WB, lumbar, hip, or regional BMC and circulating leptin concentrations among SDRBHS participants ages 20 to 55 years.

Library of Congress Subject Headings

Hutterite Brethren
Leptin
Bone densitometry
Body compositoin

Format

application/pdf

Publisher

South Dakota State University

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