PRRS continues to be the most economically important disease of swine. While the acute reproductive disease is still prevalent, chronic, or endemic PRRS in nursery and grow/finish pigs is a major problem confronting most swine producers. Post-weaning problems in these herds include a 50-85% reduction in growth rates; a 10-30% increase in unmarketable pigs; and a 10-25% increase in psot-weaning morality. Popular protocols to manage PRRSV infections include bredding herd stabilization; elmination of seronegative sub-populations of susceptible gilts; nursery depopulation; and more recently mass vaccination/unidirectional pig flow in the grow/finsih unit. The goal of this project is to determine if an isolate of PRRSV, that has been moditifed by serial passage in monkey kidney cells (MARC-145) and replicates at very low levels in procine alveolar macrophages, is avirulent for pigs an pregnant gilts.
Number of Pages
South Dakota State University
Copyright © 2001
Nelson, C.D.; Rowland, R.R.; Zeman, D.H.; and Benfield, D.A., "Evaluation of a Macrophage Attenuated Isolate of PRRSV as a
Vaccine for Porcine Reproductive and Respiratory Syndrome Virus" (2002). South Dakota Swine Research Report, 2001. 20.