This community contains the theses and dissertations of the South Dakota State University, Department of Chemistry & Biochemistry. The Department of Chemistry & Biochemistry offers Master of Science (MS) degrees in Chemistry, and an online Chemistry-Chemical Education specialization for high school teachers, Doctor of Philosophy (PhD) degrees in either Chemistry with a specialization in 4 areas:

  • Analytical Chemistry
  • Chemical Education
  • Environmental Chemistry
  • Organic Chemistry

or Biochemistry with a specialization in 2 areas:
  • Biochemistry
  • Biophysical Chemistry

Due to copyright restrictions, the collection contains both open access and university access theses and dissertations. University access items are only available to SDSU users, and on-campus visitors. Non-SDSU users wishing to access restricted materials may request items through their institution’s interlibrary loan services.

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Theses/Dissertations from 2024

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Analysis of Toxic Chemical Agents and Therapeutics for Toxic Inhaled Agents’ Exposure, Khadija Bilkis

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Elucidating The Role of Sialic Acid in Tumorigenic Pathways, Kakali Das

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Whole Genome CRISPER-Cas9 Screens Identify Genes Contributing to Viral Entry and Phagocytosis, Md Saddam Hossain

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Impact of Solar Radiation on Perchlorate Formation in the Atmosphere: Evidence from Ice Core Measurements, Bishnu Kunwar

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Primary Cilia and Intraflagellar Transport are Essential Regulators of Lymphangiogenesis and Modulate Cellular Trafficking of Ve-Cadherin, Delayna Paulson

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Comprehending the Impacts of Mutations Using Various Protein Model Systems, Ujwal Subedi

Theses/Dissertations from 2023

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Comprehensive Analysis and Forensic Investigation of Cyanide, Thiocyanate, and 2-Amino-2-Thiazoline-4-Carboxylic Acid In-Ante- and Postmortem Blood Utilizing Advanced Analytical Techniques, Abdullah Hamad Alluhayb

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Modulatory Effects of Deacetylated Sialic Acids (a Sugar Residue) in NK-Mediated Cytotoxicity and Targeted Therapy by Receptor Tyrosine Kinase Inhibitors, Mathias Tawiah Anim

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Pedagogical Content Knowledge (PCK) Change and Professional Development for Educators: An Assessment of a Master’s in Chemistry Program for High School Science Teachers, Mary Charlotte Bautista

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Understanding the Role of HBA/HBD Variations on Deep Eutectic Solvent Properties and Activity Using Acetylsalicylic Acid as a Model Drug, Michael Frimpong

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The Role of Cadherins and Ryk on Metastasis and Invasion in Triple Negative Breast Cancer Cell Model: Hs578T/Hs578Ts(i)8, Ibis Iser

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Identification and Quantification of Novel Antimicrobials, Hazera Khatun Koly

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Cytotoxicity Profiling and Apoptotic Potential of Carboxylic Acids-Based Deep Eutectic Solvents on Mammalian Cell Lines, Mavis Korankye

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Design, Synthesis, and Biological Evaluation of Novel Steroidal Analogs: Potential Anticancer Agents, Trevor Ostlund

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Advanced Analytical Techniques for the Analysis of Toxic Inhaled Agent Exposure and Pharmacokinetic Investigation, Sharmin Sultana

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Modulatory Effects of Deacetylated Sialic Acids on Breast Cancer Resistance Protein-mediated Multidrug Resistance and Receptor Tyrosine Kinase-targeted Therapy, Isaac Tuffour

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Development and Assessment of Gamified Process-Oriented Guided Inquiry Learning Activities in Undergraduate Large Lecture Chemistry Courses, Nathan Turner

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Development of Novel Cellular Assay Model and Therapeutic Deep Eutectic Solvents to Optimize the Activity of Anticancer Agents, Nizam Uddin

Theses/Dissertations from 2022

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Understanding the Impact of Human Germline Single-Nucleotide Variants, Samuel Adjei

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Diversity and Inclusion in Science Teaching Learning (DISTL): Focusing On the Perspectives of Undergraduate Students and Graduate Teaching Assistants in the Chemistry Classroom, Albert Aidoo

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The Significance of a New 11,000-Year Volcanic Record from the South Pole and Inferences from Comparisons with Other Volcanic Records, Derek Lee Brandis

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Development of a Chromatographic Method to Authenticate Aspirin Brands, Megan Guetzloff

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Formulation, Structure, and Applications of Therapeutic, Amino Acid, and Water-Based Deep Eutectic Solvents, MD Sajjadur Rahman

Theses/Dissertations from 2021

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Profiling of FDA-Approved and Clinical Trial Drugs Revealed Shared Cytotoxicity And Collateral Sensitivity In Resistant (H69ar) And Non-Resistant (H69) Small Cell Lung Cancer Cells. (Drug Repurposing in Cancer Chemotherapy), Pius Reyderg Agyemang

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Analysis of Volatile Organic Compounds: Petroleum Emissions and Microbial Degradation, A K M Ahsan Ahmed

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Advanced Analytical Techniques for the Analysis of Therapeutics of Toxic Inhalation Agents and Pharmacokinetic Investigation, Subrata Bhadra

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Analysis of Metabolites and Therapeutics for Toxic Inhaled Agent Exposure, Abigail Bemah Donkor

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Therapeutic Immunoglobulin G Surface Mobility Promotes Antibody-Dependent Cellular Phagocytosis by Arp2/3 and Syk Mediated Rearrangement of Fcγ Receptors, Seongwan Jo

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College Students Conceptions of Particulate Nature of Matter and the Impact on Research Instrumentation, Bridget Klutse

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Characterization of Cucurbitacin-Inspired Estrone Analogues as Novel Inhibitors of Human ATP- Binding Cassette Proteins (ABCB1 and ABCC1), Jennifer Kyeremateng

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Identification and Characterization of Modulators of Human MRP1 (ABCC1) and Human MRP2 (ABCC2) Expression, Vivian Osei Poku

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Novel Acetylcholine Chloride Based Water Immiscible Deep Eutectic Solvent: Formulation, Characterization and Application in Drug Solubilization, Shiksha Subedi

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An Integrative Analysis on the Role of Notch1 and Notch3 in Musculoskeletal Disease, Haydee Magdalena Torres

ETDS from 2020

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Solvolytic Lignocellulosic Biomass Liquefaction, Mustafa Alluhaibi

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Antidiabetic Activity of Cissus rotundifolia Plant Growing in Saudi Arabia, Saad Ali Alshehri

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Analysis of Coevolving Residues of xCDxCDx-PHD, A Distinct type of PHD-Finger, Shraddha Basu

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Scavenger Hunt: The Search for Sulfur Mustard-Neutralizing Compound in 2-Chloroethyl Ethyl Sulfide (CEES) Treated Human Keratinocyte (HACAT) Epithelial Cells, Tanner Diemer

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Technology-based Culturally Relevant Chemistry Education (CRCE), Mercy Adoma Fosu

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Development of Analytical Methods for Toxic Inhaled Hazards (TIH) and Their Metabolites, Obed Adu Gyamfi

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Implementing and Assessing the Use of a New Strategy for Training Chemistry Graduate Teaching Assistants, Amanda Hyett

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Screening of Catalysts for the Subcritical Water Depolymerization of Lignin, Balawanthrao Jadhav

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Volcanic Impact on Stratospheric Chlorine Chemistry and Perchlorate Formation: Evidence from Ice Cores, Joshua Andrew Kennedy

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Characterization of Naturally Derived Polymer by Oxidative, Thermal, and Spectrometric Methods, Ranen Roy

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Development and Validation of Advanced Analytical Methods for Pesticides, Per- and Polyfluoroalkyl Substances, and Opioids in Soil and Drinking Water, Christopher Skaggs

ETDS from 2019

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Novel Hybrid Analogs of Estrone Origin Exhibits Cytotoxic Effects against EGFR-dependent Cancers, Felix Acheampong

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Mass Spectrometry-Based Quantitative Proteomic Analysis of Biological Fluids, Patience Akosua Afedi

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Design, Synthesis and Biological Screening of Novel Cucs-inspired Estrone Analogs towards Treatment of Pancreatic Adenocarcinoma, Khaled Alseud

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In-Silico Design and Synthesis of Selective Estrogen Receptor Modulators Targeting Ovarian Cancer, John Apraku

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Analysis of the Molecular Mechanisms Governing FCγ Receptor Activation on the Surfaces of Macrophages by Advanced Optical Microscopy, Elizabeth Michelle Bailey

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Evaluating Green Solvents and Techniques in Extraction Methods, Shanmugapriya Dharmarajan

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Investigating Anions and Hydrophobicity of Deep Eutectic Solvents by Experiment and Computational Simulation, Amos Kwabena Dwamena

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Advanced Analysis of Compounds of Toxicological Importance by Ice Concentration Linked with Extractive Stirrer (Icecles) GC-MS and RP-HPLC-ESI-MS-MS, Joseph K. Dzisam

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Application of Analytical Techniques in Food Product Development, Sonali R. Pandey

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Discovery and Characterization of Novel Substrate Selective Inhibitors of Human MRP1 (ABCC1), Angelina Sampson

ETDS from 2018

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A Comprehensive Analysis of Aromatic-Proton Mediated Hydrogen Bonds, Mona S. Alshamrani

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Development of a High Performance Liquid Chromatography Method for the Analysis of Next-generation Cyanide Antidote, 3-mercaptopyruvate, in Plasma, Elaf Alzhrani

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Synthesis, Characterization and Molecular Dynamic Simulations of Aqueous Choline Chloride Deep Eutectic Solvents, Sampson Asare

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Study of Anti-proliferative Activity of Cucurbitacins Inspired Estrone Analogs on Hepatocellular Carcinoma, Sara Elgazwi

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Molecular Level Encapsulation of Chromophores Using Pillar[5]arenes for Enhanced Photostability, Manik Gudimani

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Role of Non-muscle Myosin II In Hs578T/Hs578Ts(i)8 Triple Negative Breast Cancer Progression, Shimara Gunawardana

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Lignin Depolymerization: Mechanistic Analysis, Optimization and Application, Eric Michael Nagel

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Fast Isotope Ratio Mass Spectrometry (FIRMS): A Tandem Mass Spectrometry Technique for the Rapid and Semi-Comprehensive Evaluation of Isotope Ratios, Fredrick Ochieng

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The Contributions of FC Gamma Receptors and Macropinocytosis to the Internalization, Sorting and Clearance of Antibody Coated Nanovesicles in Macrophages, George Opoku-Kusi Jr.

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Engineering of Two-Color ATP-Binding Cassette Biosensor Proteins for Discovery of Novel Substrates and Modulators, Bremansu Osa-Andrews

ETDS from 2017

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The Analysis of Flavor Compounds in Green Tea Using Ice Concentration Linked with Extractive Stirrer (Icecles), Abdullah H. Alluhayb

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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer, Faez Alotaibi

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Lignin Transformation and Characterization of Pyrolytic Products, Eric Amo Boakye

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Dissecting the Histone-binding Mechanism of a PHD Finger Subtype, Daniel Boamah

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Investigating the Atmospheric Production of Perchlorate: Inference from Polar Ice Cores, Thomas S. Cox

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Deep Eutectic Solvents Synthesis, Characterization and Applications in Pretreatment of Lignocellulosic Biomass, Ganesh Degam

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CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages, Lu Huang

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Self-Assembled Architecture of Natural Organic Matter, Cynthia Johnson-Edler

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Comprehensive Structural, Thermal and Toxicological Characterization of 1-Ethyl-3-Methylimidazolium Alkylbenzenesulfonate Ionic Liquids, Hiranmayee Kandala

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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma, Mater Hussen Mahnashi

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Analysis of Novel Cyanide Antidote Dimethyl Trisulfide for Pharmacokinetic Studies, and Sulfur Mustard Metabolites for Identification of Biomarker of Inhaled Dose, Erica Manandhar

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The Relationship Between Recollection, Knowledge Transfer, and Student Attitudes Towards Chemistry, Oluwatobi Omobonike Odeleye

ETDS from 2016

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Environmentally Benign Extraction Processes in Analytical Separation of Essential Oils, John Kiratu

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Ice Concentration Linked with Extractive Stirrer (ICECLES), Nujud Omar Maslamani

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A FRET Investigation into Molecular Mechanisms of Cardiac Troponin Activation in Reconstituted Thin Filaments, Maria Eleni Moutsoglou

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Innate Immunity and Peptide Based Antiviral Development Against Porcine RNA Viruses of Nidovirales, Martha Marie Ohnstad

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Perchlorate Variations Over 300 Years: Influence of Human Activities, Volcanic Eruptions and Bolide Events, Kari Peterson

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Use of Extraction Technologies in Food Safety Studies, Changling Qiu

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Mechanistic Studies of the Structure-Photostability Relationship of Organic Conjugated Polymers, Logan Paul Sanow

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Functional Effects of Calcium Regulation of Thin Filaments at Single Particle Resolution, Christopher Solis-Ocampo

ETDS from 2015

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Characterization and High-Temperature Hydrotreatment of Lignin Using Carbon-Loaded Catalysts, Tanvir Amit

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Development of Liquid Chromatography-Mass Spectrometric Methods for the Analysis of Nerve Agent Hydrolysis Products from Hair and Nail for Long-Term Verification of Nerve Agent Exposure, Amanda S. Appel

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Discovery of Novel Readers for Interpretation of the Epigenome, Francisca Essel

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Application of Supercritical Carbon Dioxide in Agricultural Products Processing, George Gachumi

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Synthesis of Functionalized Carboxylate Deposition Materials for DSSC and New Chromatography Stationary Phases, Anay Kumar Kudire

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Mitsunobu Reactions of Bulky Phenols and Lignin Model Dimer Synthesis & Decomposition, Dan Liu

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Advances in FRET Microscopy for the Analysis of multiple Protein-protein Interactions in the Three-dimensional Space of the Living Cell, Brandon L. Scott

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Liquid Chromatography-tandem Mass Spectrometry of Next-generation Cyanide Antidotes, 3-mercaptopyruvate and Cobinamide, with the Pharmacokinetic Analysis of 3-mercaptopyruvate, Michael W. Stutelberg

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Organic Pi-conjugated Materials : Photochemical Stability and Photovoltaic Cell, Jianyuan Sun

ETDS from 2014

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Anticancer and Antiviral Activities of Cucurbitacins Isolated From Cucumis Prophetarum var. Prophetarum Growing in the Southwestern Region of Saudi Arabia, Abdulrhman Saleh Alsayari

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The Development of a Field Sensor for the Rapid Detection of Cyanide Exposure, Randy E. Jackson

ETDS from 2013

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Design, Synthesis, and Biological Screening of Novel Cucurbitacin/ Estrone Analogs Towards Treatment of Melanoma, Mahmoud Salama Ahmed

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Investigation onto the Mechanism Behind the Hepatoprotective Effect of Cucurbitacin Compounds, Hajer Arjaibi

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Comprehensive Structural and Thermal Characterization of Selected Grass Lignins, Vinod Bathula

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The Toxicokinetic Behavior of Cyanide, Thiocyanate and 2-Amino-2-Thiazoline-4-Carboxylic Acid Following Cyanide Exposure in Multiple Animal Models Utilizing Novel Methods of Detection, Raj K. Bhandari

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Three Hundred Year Record of Part Per Trillion (PPT)-level Perchlorate Measured with Ion Chromatography with Tandem Mass Spectrometry (IC - MS/MS), Derek Lee Brandis