Document Type

Article

Publication Date

2010

Keywords

cyanide, thiocyanate, 2-amino-2-thiazoline-4-carboxylic acid (ATCA), chemical warfare agent, exposure, toxicology, analytical methods

Abstract

Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems.

Publication Title

Critical Reviews in Analytical Chemistry

Volume

40

Issue

2

First Page

122

Last Page

147

Pages

26

Format

application/pdf

Language

en

DOI of Published Version

10.1080/10408340903535315

Publisher

Taylor and Francis

Rights

Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S.

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