cyanide, thiocyanate, 2-amino-2-thiazoline-4-carboxylic acid (ATCA), chemical warfare agent, exposure, toxicology, analytical methods
Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems.
Critical Reviews in Analytical Chemistry
DOI of Published Version
Taylor and Francis
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Logue, Brian A.; Hinkens, Diane M.; Baskin, Steven I.; and Rockwood, Gary A., "The Analysis of Cyanide and its Breakdown Products in Biological Samples" (2010). Chemistry and Biochemistry Faculty Publications. 35.