Residual effects of maternal consumption of metal amino acid complexes in offspring inflammatory and oxidative status during the weaning period.
American Dairy Science Association
Journal of Dairy Science
weaning, trace minerals, calves
Maternal diets fed during late pregnancy (close-up) to dairy cows have been observed to have a significant effect on the offspring’s immune status and health during the neonatal stage. Our objective was to evaluate the effect of maternal consumption of organic trace minerals supplemented during late pregnancy on offspring’s immune and oxidative status during the weaning period. Forty multiparous Holstein cows were supplemented for 30 d prepartum to supply 40, 20, 5, and 1 mg/ kg of Zn, Mn, Cu, and Co from either metal amino acid complexes (AAC) or sulfate (INO) sources (total diet contained supplemental 75, 65, 11, and 1 mg/kg of Zn, Mn, Cu, and Co, and additional Zn, Mn, and Co provided by sulfates). A subset of calves (n = 8/trt) born to dams enrolled in the trial was used for growth and performance data and blood immunometabolic markers. Calves were housed in individual hutches from birth to 7 wk of age and intakes of milk replacer and starter were measured daily. Calves were fed the same nutritional program with 2 × /d feeding milk replacer from wk 1 to 5, 1 × /d feeding during wk 6 (36 to 42 d of age), and weaning at wk 7 (43 d of age). Starter grain was offered ab libitum. Fecal and respiratory scores were recorded daily. Blood samples were taken pre-weaning and post-weaning at 40 and 50 d of age, respectively. Body weight (BW) and withers height (WH) were recorded weekly. Data were analyzed using the MIXED procedure of SAS. Overall BW was not affected (P = 0.77) by maternal 136 J. Dairy Sci. Vol. 101, Suppl. 2 AAC, however, there was a trend (P = 0.07) for greater withers height in AAC calves. The AAC calves had overall lower paraoxonase (P = 0.02) and myeloperoxidase(P = 0.03), while greater ferric reducing antioxidant power (FRAP; P = 0.04) in comparison to INO calves. A trend for lower glutamic-oxaloacetic transaminase (GOT; P = 0.06), γ-glutamyltransferase (GGT; P = 0.06), and reactive oxygen metabolites (ROM; P = 0.10) was observed in AAC calves than INO. These data suggest that maternal consumption of AAC can have long-lasting effects in the offspring by reducing oxidative stress and potentially alter liver function during stress periods such as weaning.
Grazziotin, R. C. B.; Jacometo, C. B.; Socha, M.; Trevisi, E.; Loor, J. J.; and Osorio, J. S., "Residual effects of maternal consumption of metal amino acid complexes in offspring inflammatory and oxidative status during the weaning period." (2018). Dairy Science Publication Database. 1992.