Session 3: An ‘Arg’ to Comprehend Genetic Constraint
Presentation Type
Invited
Student
No
Track
Other
Abstract
As germline variants are filtered through natural selection, macro-genetic data on millions of germline variants obtained from next-generation sequencing (NGS) from a large human population provide an important avenue to address fundamental questions on selection pressure and genetic constraints such as probing the depletion of germline variants to gain functional insight into genetic constraints. Our study focuses on translating genetic constraints at the level of amino acid to probe protein function.
Start Date
2-7-2023 9:50 AM
End Date
2-7-2023 10:50 AM
Session 3: An ‘Arg’ to Comprehend Genetic Constraint
Herold Crest 253 C
As germline variants are filtered through natural selection, macro-genetic data on millions of germline variants obtained from next-generation sequencing (NGS) from a large human population provide an important avenue to address fundamental questions on selection pressure and genetic constraints such as probing the depletion of germline variants to gain functional insight into genetic constraints. Our study focuses on translating genetic constraints at the level of amino acid to probe protein function.