Relationships Between Bone Mass and Circulating Leptin Concentrations in Hutterites

Document Type

Article

Publication Date

6-1-2004

Keywords

Adult, Analysis of Variance, Body Mass Index, Body Weight, Bone Density, Female, Humans, Leptin, Male, Middle Aged, Regression Analysis, South Dakota

Abstract

A limited number of previous studies have shown inverse associations between bone mass or density and circulating leptin in humans. Relationships between bone mass and circulating leptin in Hutterites, who have elevated bone density, are unknown. Knowledge gained from studies in mice suggests that Hutterites exhibit traits consistent with a deficiency in circulating leptin or in leptin signaling. We examined relationships between whole body (WB) and regional (lumbar, total hip, femoral neck, trochanter) bone mineral content (BMC) by dual energy X-ray absorptiometry and circulating leptin in 249 Hutterites (137 female) ages 20-55 years and 72 similarly aged non-Hutterites (37 female). We tested the hypothesis that (1) Hutterites will have low circulating leptin concentrations for a given amount of body fat compared to non-Hutterites, and (2) controlling for body fat, there will be an inverse relationship between BMC and circulating leptin among Hutterites. Hutterites had higher BMC than non-Hutterites at all skeletal sites after adjusting for site-specific bone area, age, and sex (P

Publication Title

Bone

Volume

34

Issue

6

First Page

1017

Last Page

1022

DOI of Published Version

10.1016/j.bone.2004.01.006

PMID

15193548

Publisher

Elsevier Science

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