Document Type

Thesis - Open Access

Award Date


Degree Name

Master of Science (MS)

Department / School

Pharmaceutical Sciences


Of the many anti-epileptic agents available, the most commonly used compounds can be divided into four categories: the barbiturates and related drugs, the hydantoins, the oxazolidines and the succinimides. Because of the possibility of concurrent use of the compounds in the treatment of epilepsy, it would be advantageous to have some information concerning the effect that each group has individually on microsomal enzyme systems before therapy in instituted. This information would enable the clinician to more adequately predict drug response thus reducing dosage regimen adjusting time and also possibly reducing the incidence of adverse reactions or interactions. The effect of both phenobarbital and diphenylhydantoin on microsomal enzyme activity has been previously explored and the objective of this study was to investigate what effects the administration of trimethadione and ethosuximide would have under similar circumstances. Little or o information has been published on the influence of the latter two compounds on demethylase activity. For this study the barbiturates were represented by phenobarbital, the hydantoins by diphenylhydantoin, the oxazolidines by trimethadione, and the succinimides by ethosuximide. Following short term administration of each agent, the microsomal demethylase activity of rat liver was determined. Dosage were approximately five times the recommended normal human daily dose for each of the agents.

Library of Congress Subject Headings

Drugs -- Research




Number of Pages



South Dakota State University