Document Type
Thesis - Open Access
Award Date
2016
Degree Name
Master of Science (MS)
Department / School
Health and Nutritional Sciences
First Advisor
Gary P. Van Guilder
Abstract
A powerful therapy against microvascular endothelial ischemia-reperfusion injury is remote ischemic preconditioning (rIPC), which triggers tissue protection by exposing a limb to small cycles of vascular occlusion. Animal models indicate that CVD risk factors reduce the protective benefits of ischemic conditioning. However, there are no human studies investigating how a burden of risk factors interferes with rIPC to prevent endothelial injury. The purpose of the present study was to determine the influence of risk factor burden on the capacity of rIPC to prevent endothelial reperfusion injury in humans. Twenty-two (age: 45±14 yr., BMI: 31±8 kg/m2) sedentary adults (12 lower burden: ≤2 risk factors; 10 raised burden: 3-5 risk factors) were studied. Digital arterial tonometry (EndoPAT 2000, Itamar Medical Inc.) was used to assess microvascular endothelial vasodilation during reactive hyperemia before and after 65 min of left arm reperfusion injury (20 min brachial artery ischemia followed by 45 min reperfusion) that was preceded by rIPC (right arm: 3X5 min ischemia/reperfusion). All subjects provided written informed consent according to the Internal Review Board guidelines at South Dakota State University. Repeated measures ANOVA was used to assess group differences between the reactive hyperemia index (RHI) before and after reperfusion injury. Statistical significance was set at P
Library of Congress Subject Headings
Cardiovascular system -- Diseases -- Risk factors
Heart -- Diseases -- Risk factors
Reperfusion injury -- Prevention
Myocardial infarction -- Prevention
Cardiotonic agents
Description
Includes bibliographical references (page 64-70)
Format
application/pdf
Number of Pages
79
Publisher
South Dakota State University
Recommended Citation
Trachte, Tiffany, "Influence of Cardiovascular Risk factors on Remote Ischemic Preconditioning" (2016). Electronic Theses and Dissertations. 983.
https://openprairie.sdstate.edu/etd/983
Included in
Exercise Physiology Commons, Exercise Science Commons, Medicine and Health Sciences Commons
Comments
Cardiovascular system -- Diseases -- Risk factors
Heart -- Diseases -- Risk factors
Reperfusion injury -- Prevention
Myocardial infarction -- Prevention
Cardiotonic agents