Document Type

Article

Publication Date

6-1-2014

Keywords

Blood Glucose, Body Composition, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Comorbidity, Cross-Over Studies, Diet, Dietary Fiber, Double-Blind Method, Female, Flour, Humans, Male, Metabolic Syndrome, Prebiotics, Starch, United States, Waist Circumference

Abstract

A metabolic health crisis is evident as cardiovascular diseases (CVD) remain the leading cause of mortality in the United States. Effects of resistant starch type 4 (RS4), a prebiotic fiber, in comprehensive management of metabolic syndrome (MetS) remain unknown. This study examined the effects of a blinded exchange of RS4-enriched flour (30% v/v) with regular/control flour (CF) diet on multiple MetS comorbidities. In a double blind (participants-investigators), placebo-controlled, cluster cross-over intervention (n = 86, age≥18, 2-12 week interventions, 2-week washout) in the United States, individuals were classified as having MetS (With-MetS) or not (No-MetS) following International Diabetes Federation (IDF)-criteria. RS4 consumption compared with CF resulted in 7.2% (p = 0.002) lower mean total cholesterol, 5.5% (p = 0.04) lower non-HDL, and a 12.8% (p < 0.001) lower HDL cholesterol in the With-MetS group. No-MetS individuals had a 2.6% (p = 0.02) smaller waist circumference and 1.5% (p = 0.03) lower percent body fat following RS4 intervention compared to CF. A small but significant 1% increase in fat-free mass was observed in all participants combined (p = 0.02). No significant effect of RS4 was observed for glycemic variables and blood pressures. RS4 consumption improved dyslipidemia and body composition. Incorporation of RS4 in routine diets could offer an effective strategy for public cardio-metabolic health promotion.

Publication Title

Molecular Nutrition & Food Research

Volume

58

Issue

6

First Page

1365

Last Page

1369

PMCID

PMC4048643

DOI of Published Version

10.1002/mnfr.201300829

Publisher

Wiley Online

Rights

Copyright © 2014 Wiley

Comments

This is the pre-peer reviewed version of the following article: Mol Nutr Food Res. 2014 Jun;58(6):1365-9. doi: 10.1002/mnfr.201300829. Epub 2014 Jan 30., which has been published in final form at https://doi.org/10.1002/mnfr.201300829. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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