The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance

Authors

M M Pretorius
J V Gainer
Gary Van GuilderFollow
E B Coelho
J M Luther
P Fong
D D Rosenbaum
H A Malave
C Yu
M D Ritchie
D E Vaughan
N J Brown

Document Type

Article

Publication Date

1-1-2008

Abstract

We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P

Publication Title

Clinical pharmacology and therapeutics

Volume

83

Issue

1

First Page

122

Last Page

129

DOI of Published Version

10.1038/sj.clpt.6100250

Publisher

American Society for Clinical Pharmacology and Therapeutics

Recommended Citation

Pretorius, M M; Gainer, J V; Van Guilder, Gary; Coelho, E B; Luther, J M; Fong, P; Rosenbaum, D D; Malave, H A; Yu, C; Ritchie, M D; Vaughan, D E; and Brown, N J, "The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance" (2008). Health and Nutritional Sciences Faculty Publications. 55.
https://openprairie.sdstate.edu/hns_pubs/55