Document Type
Article
Publication Date
6-30-2016
Keywords
Adipokines, Bacteroides, Case-Control Studies, DNA, Bacterial, Diet, Eubacterium, Fatty Acids, Volatile, Feces, Gas Chromatography-Mass Spectrometry, Gastrointestinal Microbiome, Humans, Metabolic Syndrome, Principal Component Analysis, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Starch, Waist Circumference
Abstract
Dietary modulation of the gut microbiota impacts human health. Here we investigated the hitherto unknown effects of resistant starch type 4 (RS4) enriched diet on gut microbiota composition and short-chain fatty acid (SCFA) concentrations in parallel with host immunometabolic functions in twenty individuals with signs of metabolic syndrome (MetS). Cholesterols, fasting glucose, glycosylated haemoglobin, and proinflammatory markers in the blood as well as waist circumference and % body fat were lower post intervention in the RS4 group compared with the control group. 16S-rRNA gene sequencing revealed a differential abundance of 71 bacterial operational taxonomic units, including the enrichment of three Bacteroides species and one each of Parabacteroides, Oscillospira, Blautia, Ruminococcus, Eubacterium, and Christensenella species in the RS4 group. Gas chromatography-mass spectrometry revealed higher faecal SCFAs, including butyrate, propionate, valerate, isovalerate, and hexanoate after RS4-intake. Bivariate analyses showed RS4-specific associations of the gut microbiota with the host metabolic functions and SCFA levels. Here we show that dietary RS4 induced changes in the gut microbiota are linked to its biological activity in individuals with signs of MetS. These findings have potential implications for dietary guidelines in metabolic health management.
Publication Title
Scientific Reports
Volume
6
First Page
28797
Last Page
28797
Format
application/pdf
PMCID
PMC4928084
DOI of Published Version
10.1038/srep28797
Publisher
Nature Publishing
Rights
Copyright © 2016 the Author(s)
Recommended Citation
Upadhyaya, Bijaya; McCormack, Lacey; Fardin-Kia, Ali Reza; Juenemann, Robert M.; Nichenametla, Sailendra; Clapper, Jeffrey A.; Specker, Bonny; and Dey, Moul, "Impact of Dietary Resistant Starch Type 4 on Human Gut Microbiota and Immunometabolic Functions" (2016). Health and Nutritional Sciences Faculty Publications. 86.
https://openprairie.sdstate.edu/hns_pubs/86
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.