Faculty Mentor

Brian A. Logue


Cyanide poisoning is a public concern, and there are many shortfalls in current cyanide treatments. Dimethyl trisulfide (DMTS) is a cyanide antidote candidate that overcomes these shortfalls. Currently, there are limited published reports related to the analysis of DMTS. Therefore, an analytical method to detect and analyze DMTS from a biological matrix is vital for it to become available as a therapeutic agent against cyanide poisoning. The motivation of this project is to develop an HPLC-MS/MS method for analysis of DMTS and its degradation products; however, DMTS is difficult to ionize, a requirement for MS analysis, due to its nonpolar nature. In this study, DMTS was oxidized to a more polar compound that should enable its MS-MS analysis. The oxidation reaction was optimized to maximize product yield and, therefore, improve the accuracy of the analytical technique. The optimized oxidation reaction increased the yield of oxidized DMTS by 17.4% and decreased the amount of un-oxidized DMTS by 88.5%. In addition, initial characterization of the reaction product was preformed, using GC-MS. The preliminary results indicated the DMTS was fully oxidized.

Included in

Chemistry Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.