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Document Type
Thesis - University Access Only
Award Date
1989
Degree Name
Master of Science (MS)
Department / School
Foods and Nutrition
First Advisor
Michael J. Crews
Abstract
Human adipose tissue was analyzed for organochlorine pesticide residues. The specimens were obtained from unembalmed cadavers. Demographics and information regarding the subjects' medical history was obtained from the medical charts. Subjects' ages ranged from 53 to 81 years. All subjects were male. The diseases of greatest incidence were cardiovascular disease and malignancy. All samples were analyzed by packed-column gas chromatography and peaks were confirmed on a secondary column. Quantitation was determined by standard methodology. Levels of o,p' DDT tended to increase with age. The occupation with the highest levels of heptachlor epoxide was the farmers/ranchers. Heptachlor epoxide levels were highest in the rural category. Subjects with cardiovascular disease and chronic obstructive pulmonary disease had higher hexachlorobenzene levels than subjects with malignancy. Because these chemicals are readily retained in adipose tissue, some important questions should be raised. Do the current pesticide levels in adipose tissue pose a risk to our health? Some of these chemicals were banned in U.S. in the 1970's but are still used in other countries. Are the pesticide residues on the food imported into the U.S. affecting our health? The purpose of this research was to analyze the current level of selected organochlorine pesticides in humans in relation to chronic disease state, medical history, employment, residence and age. The intent of the research was to yield information that could assist in understanding organochlorine biotransformation and its effects in the human body.
Library of Congress Subject Headings
Organochlorine compounds -- Physiological effects
Pesticides -- Physiological effects
Adipose tissues -- Analysis
Format
application/pdf
Number of Pages
141
Publisher
South Dakota State University
Recommended Citation
DeSmet, Lisa J., "Organochlorine Pesticide Residues in Human Adipose Tissue in Relation to Disease State" (1989). Electronic Theses and Dissertations. 4569.
https://openprairie.sdstate.edu/etd/4569