Document Type

Thesis - University Access Only

Award Date

2012

Degree Name

Master of Science (MS)

Department / School

Health and Nutritional Sciences

First Advisor

Matthew Vukovich

Abstract

Objectives - The aim of this pilot cross-sectional study was to assess the vitamin D status and muscle function in children with NF1 compared with their unaffected siblings. Methods - NF1 children between five and 18 years of age and who had at least one unaffected sibling were identified. Serum concentrations of 25-hydroxyvitamin D, calcium, inorganic phosphate, alkaline phosphate, parathyroid hormone and 1,25-dihydroxyvitamin D were measured. The Leonardo Mechanography Ground Reaction Force Platform was used to measure EFI, jumping power, force and jump height. Results - There was no significant difference in 25(OH)D between NF1 subjects and the unaffected siblings. Peak jumping power and force were found to be significantly different, after controlling for body mass and age. The adjusted means (95% confidence limits) for peak jumping power (kW) were 1.68 (1.54, 1.83) and 1.39 (1.25, 1.54) (P< 0.0001 ); force (kN) 1.10 (1.04, 1.16) and 0.88 (0.82, 0.94) (P< 0.0001); and jump height (m) 0.35 (0.27, 0.44) and 0.31 (0.22, 0.39) (p=0.43), respectively. Jumping parameters were not shown to be related to serum 25(OH)D concentrations. Conclusions - There was no significant relationship between vitamin D status and NF1 status in children. NF1 children had significantly impaired jumping power and force, when compared to the unaffected siblings.

Library of Congress Subject Headings

Neurofibromatosis in children 
Vitamin D in human nutrition 
Muscles

Publisher

South Dakota State University

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Rights Statement

In Copyright